Tsi mawan hte malu masha hpaga lam ni hta, capsule tsi ladat ni hpe grai lang ai gaw, htaw sa na matu loi ai hte n kaja ai manam pyaw ai baw ni hpe makoi magap da lu ai majaw re. Dai ni hta, enteric-coated capsules ni gaw, laksan bungli galaw ai tsi mawan langai hku nna, ahkyak ai lit nga ai. Hpaga lam (sh) R&D galaw ai aten hta, tsi hpaga hpung law law gaw, madung masat kumla langai hpe madung tawn ma ai: Enteric-coated capsules ni a garan ginhka ai aten gaw kade daram rai kun? Ndai laika hta ndai lam hpe sung sung li li sawk sagawn nna, enteric-coated capsules ni a garan ginhka ai lam a arawn alai hte ahkyak ai lam hpe sung sung chye na la lu na matu karum ya na re.
I. Enteric-Ka-up da ai Capsule ni a masat da ai garan ginhka ai aten
Miwa tsi laika buk hte seng ang ai mungdan madang ni hte maren, enteric-coated hard capsules ni a garan pru ai aten hpe grai hkrak hkra masat da ai. Tsun mayu ai gaw, shi a garan ginhka ai lam hpe, shinggyim hkum hkrang kata na n bung ai shat shadu sha ai daw ni a grup yin ni hte htap htuk ai hku nna, daw lahkawng garan nna galaw ai:
Hkum hkrang ntsin grup yin (Acid-hkap la lu ai lahkam):
Enteric capsules ni gaw, n-gun n rawng ai sha, n-gun n rawng ai sha, n-gup n-gu hta ngang grin nga ra ai. Dai madang hta, n-gun rawng ai ntsin (pH 1.2 hydrochloric acid solution) hta n-gun rawng ai ntsin (pH 1.2 hydrochloric acid solution) hta shinggrup ai (sh) hkying hkum 2 laman, n-gun rawng ai ntsin hta n-gun n rawng ai, n-gun n rawng ai, n-gun n rawng ai kumla ni n nga ra ai ngu tsun da ai. Ndai hku galaw ai gaw, tsi gaw hkum hkrang kata hku shim lum ai hku lai wa lu na matu, gastric acid gaw tsi a daw ni hpe jahten kau na matu (sh) tsi gaw hkum hkrang n-gun hpe n-gun n jaw na matu re.
Hkum hkrang ntsin grup yin (Hten run mat ai lahkam):
Dai capsule gaw n-gup kata de shang wa ai shaloi, tsi hpe lawan ladan shapraw kau ra ai. Ndai madang hta, n-gup n-gu hta chyam yu ai capsule hpe, n-gup n-gu n-gun (pH 6.8 phosphate buffer) de htawt bang ra ai, dai shara hta shi a garan pru ai aten gaw, minit 60 laman hta rai ra ai (madang tsaw ai nkau mi gaw, minit 30 laman zawn re ai aten kadun ra ai). Dai aten gaw, galaw shapraw ai wa a ladat hte hkrang masa hta hkan nna loi mi shai hkat ai, raitim, madung tara gaw "hkum hkrang de du ai shaloi, garan mat wa ai" ngu ai rai nga ai.
Dai majaw, enteric-coated capsules ni a htum mat ai aten gaw, jahpan langai sha n rai, "hkum hkrang ntsin hta htum mat ai lam n nga ai ( Hkying hkum 2 hta grau ai (sh) dai hte maren)" hte "hkum hkrang ntsin hta lawan ai hku htum mat ai ( Minit 60 hta n law ai (sh) dai hte maren)" ngu ai hpe hkum tsup ai hku madun dan ai lam rai nga ai.
II. Hpa majaw garan ginhka ai aten gaw grai ahkyak ai kun?
Enteric-kap ai capsule ni a hkrang shapraw yaw shada ai lam gaw "site-hpe laksan shapraw ai" re. Disintegration aten gaw n kaja ai rai yang, grai sawng ai akyu ni byin chye ai:
N aten garai n du yang htum mat ai (Hkum hkrang hta): Ndai lam gaw tsi hpe gastric acid a majaw hkra machyi shangun nna, tsi a akyu hpe shayawm kau ya lu ai; shing nrai, tsi gaw hkum hkrang hpe n-gun ja shangun nna, n-gup n-gu, n-gup n-gu zawn re ai n kaja ai akyu ni byin shangun chye ai.
Delayed Disintegration (In the Intestine): Capsule gaw n-gup kata grai lawan ai hku garan mat yang, tsi hpe n-gup kaji kata na kaja dik ai hkam la ai shara kaw n mai shapraw ai majaw, hkam la ai lam yawm mat ai (sh) n shapraw shi yang hkum hkrang kaw na pyi pru mat wa chye ai.
Dai majaw, garan ginhka ai aten hpe atsawm sha hkang lu ai gaw, tsi a bioavailability hte tsi ladat a akyu hpe hkam la lu na matu ahkyak ai lam rai nga ai.
III. Hten za ai aten hpe hkra machyi shangun ai lam ni
Mungdan madang ni hta langai sha re ai tara masa ni nga tim, tatut jai lang ai shaloi, garan ginhka ai aten hpe lam amyu myu a majaw shadut ya lu ai:
Raw Material Hkrang: Madang tsaw ai n-gup n-gu tsi ni hta, n-gup n-gu n-gun rawng ai arung arai ni (Cellulose Acetate Phthalate CAP, Acrylic resin, etc.) hte ka-up da ai gelatin hpe lang chye ai. Dai coating layer a galu kaba ai lam hte langai sha re ai lam gaw acid hpe ninghkap ai aten hte garan pru wa ai lawan ai lam hpe hkrak dawdan ya ai.
Hkamja lam hte seng nna, hka lim ai hte katsi ai gaw capsule shell hpe grai hkra machyi shangun ai. Grai hka lim ai majaw, capsule shell gaw n-gun yawm mat nna, shi a hkum hkrang atsam ni hpe galai shai kau ya nna, dai hku nna, garan mat ai aten hpe hkra machyi shangun chye ai.
Nature of Contents: Hpring tsup ai tsi n-gun (sh) granules ni hta hygroscopicity (sh) laksan pH madang ni nga yang, capsule arung arai ni hte matut mahkai nna, n-gun n rawng ai hku garan pru wa ai lam hpe pat shingdang chye ai.
IV. Daw dan lam
Tsun ga nga yang, 2019 ning a garan ginhka ai aten gaw kade rai ta?enteric-kap da ai tsi mawan ni? Mahtai gaw: artificial gastric fluid hta hkying hkum 2 laman n garan mat ai, law malawng gaw artificial n-gup ntsin hta hkying hkum 1 laman garan mat chye ai. Tsi hpaga hpung ni a matu, tsi mawan masat masa ni hpe hkan sa nna, ngang grin ai hkam kaja lam hpe jaw ya ai enteric-coated capsules ni hpe jaw ya ai wa hpe lata la ai gaw, tsi mawan shimlum lam hte akyu rawng ai lam hpe hkam la lu na matu ra kadawn ai lam rai nga ai. Hpaga ga ai aten hta, dai arung arai gaw na a laksan galaw ra ai lam ni hpe hkan sa lu na matu, garan ginhka ai aten hpe chyam dinglik na matu sample ni hpe teng sha hpyi shawn u. Empty capsule hte seng nna ga san san mayu ai ni nga yang, KornnacCaps hte matut mahkai na matu hkap tau la ga ai.
